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Risk of Bias Assessment Skill
risk-of-bias
Assess risk of bias in research studies for systematic reviews. Use when: (1) Conducting systematic reviews, (2) Evaluating study quality, (3) GRADE assessments, (4) Meta-analysis planning.
SKILL.md
Full skill instructions
Risk of Bias Assessment Skill
Purpose
Systematically evaluate methodological quality and potential biases in research studies.
Tools by Study Design
RCTs: Cochrane Risk of Bias 2 (RoB 2) Non-randomized: ROBINS-I Diagnostic Studies: QUADAS-2 Prognostic Studies: QUIPS
RoB 2 Domains
-
Randomization Process
- Adequate sequence generation?
- Allocation concealment?
-
Deviations from Interventions
- Blinding effective?
- Adherence to protocol?
-
Missing Outcome Data
- Complete data?
- Appropriate handling?
-
Outcome Measurement
- Blinded assessment?
- Validated measures?
-
Selective Reporting
- All outcomes reported?
- Pre-registered?
Risk Levels
- Low: Minimal bias
- Some concerns: Potential bias
- High: Serious bias likely
Integration
Use with literature-reviewer agent for systematic quality assessment of included studies.
Version: 1.0.0
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