experiment-design
Design rigorous experiments following best practices. Use when: (1) Planning research studies, (2) Grant proposal development, (3) Pre-registration, (4) Ensuring internal validity, (5) Meeting NIH rigor standards.
SKILL.md
Full skill instructions
Experiment Design Skill
Purpose
Design methodologically rigorous experiments with appropriate controls and randomization.
Key Design Elements
1. Research Question: Clear, testable hypothesis 2. Study Design: RCT, quasi-experimental, observational 3. Sample Size: Power analysis justified 4. Randomization: Method specified 5. Blinding: Who is blinded 6. Controls: Appropriate comparison groups 7. Outcomes: Primary and secondary clearly defined 8. Analysis Plan: Pre-specified statistical approach
Common Designs
Between-Subjects: Different participants per condition Within-Subjects: Same participants, repeated measures Factorial: Multiple factors (2x2, 2x3) Crossover: Participants receive all treatments Stepped-Wedge: Phased rollout
NIH Rigor Checklist
- Scientific premise established
- Rigorous design (appropriate controls)
- Biological variables considered (SABV)
- Authentication of key resources
- Transparent reporting planned
Version: 1.0.0