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Clinical Trial Matcher

---name: clinical-trial-matcher description: Matches patient profiles to open clinical trials using vector similarity and inclusion/exclusion criteria. Use when a user provides patient data and asks for relevant trials.

SKILL.md

Full skill instructions

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Clinical Trial Matcher

This skill matches a patient's clinical profile against a database of active clinical trials (ClinicalTrials.gov).

When to use this skill

  • When the user provides a patient case summary, medical history, or specific diagnosis.
  • When the user explicitly asks to "find trials" or "recruit patients".
  • When evaluating eligibility criteria for a specific trial.

How to use it

  1. Extract Patient Data: Identify key demographics (age, sex), primary diagnosis, stage of disease, and prior lines of therapy from the user's input.
  2. Search Vector Database:
    • Generate an embedding for the patient summary.
    • Query the trials_vector_db for top 20 semantic matches.
  3. Filter by Logic:
    • Apply hard filters: status=Recruiting, phase!=Terminated.
    • Check inclusion/​exclusion criteria (e.g., "Must have EGFR mutation", "No prior immunotherapy").
  4. Format Output:
    • Present matches in a structured list: Trial ID (NCT number), Title, Phase, and "Why it fits" (matching logic).
    • Highlight any potential exclusion criteria that need verification.

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