Adaptyv

adaptyv

Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting exp...

Dicklesworthstone/pi_agent_rust·0installs1.8Kstars

SKILL.md

Full skill instructions

Adaptyv

Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein sequences via API or web interface and receive experimental results in approximately 21 days.

Quick Start

Authentication Setup

Adaptyv requires API authentication. Set up your credentials:

Contact [email protected] to request API access (platform is in alpha/beta)
Receive your API access token
Set environment variable:

export ADAPTYV_API_KEY="your_api_key_here"

Or create a .env file:

ADAPTYV_API_KEY=your_api_key_here

Installation

Install the required package using uv:

uv pip install requests python-dotenv

Basic Usage

Submit protein sequences for testing:

import os
import requests
from dotenv import load_dotenv

load_dotenv()

api_key = os.getenv("ADAPTYV_API_KEY")
base_url = "https://kq5jp7qj7wdqklhsxmovkzn4l40obksv.lambda-url.eu-central-1.on.aws"

headers = {
    "Authorization": f"Bearer {api_key}",
    "Content-Type": "application/json"
}

# Submit experiment
response = requests.post(
    f"{base_url}/experiments",
    headers=headers,
    json={
        "sequences": ">protein1\nMKVLWALLGLLGAA...",
        "experiment_type": "binding",
        "webhook_url": "https://your-webhook.com/callback"
    }
)

experiment_id = response.json()["experiment_id"]

Available Experiment Types

Adaptyv supports multiple assay types:

Binding assays - Test protein-target interactions using biolayer interferometry
Expression testing - Measure protein expression levels
Thermostability - Characterize protein thermal stability
Enzyme activity - Assess enzymatic function

See reference/experiments.md for detailed information on each experiment type and workflows.

Protein Sequence Optimization

Before submitting sequences, optimize them for better expression and stability:

Common issues to address:

Unpaired cysteines that create unwanted disulfides
Excessive hydrophobic regions causing aggregation
Poor solubility predictions

Recommended tools:

NetSolP / SoluProt - Initial solubility filtering
SolubleMPNN - Sequence redesign for improved solubility
ESM - Sequence likelihood scoring
ipTM - Interface stability assessment
pSAE - Hydrophobic exposure quantification

See reference/protein_optimization.md for detailed optimization workflows and tool usage.

API Reference

For complete API documentation including all endpoints, request/response formats, and authentication details, see reference/api_reference.md.

Examples

For concrete code examples covering common use cases (experiment submission, status tracking, result retrieval, batch processing), see reference/examples.md.

Important Notes

Platform is currently in alpha/beta phase with features subject to change
Not all platform features are available via API yet
Results typically delivered in ~21 days
Contact [email protected] for access requests or questions
Suitable for high-throughput AI-driven protein design workflows

Install skill

Copy and run in your terminal

npx -y skills add https://github.com/Dicklesworthstone/pi_agent_rust --skill adaptyv

View on GitHub

tests/ext_conformance/artifacts/templates-davila7/cli-tool/components/skills/scientific/adaptyv/SKILL.md

deepgram-hello-world
Create a minimal working Deepgram transcription example. Use when starting a new Deepgram integration, testing your setup, or learning basic Deepgram API patterns. Trigger with phrases like "deepgram hello world", "deepgram example", "deepgram quick start", "simple transcription", "transcribe aud...
0 installs
interactive-shell
Cheat sheet + workflow for launching interactive coding-agent CLIs (Claude Code, Gemini CLI, Codex CLI, Cursor CLI, and pi itself) via the interactive_shell overlay or headless dispatch. Use for TUI agents and long-running processes that need supervision, fire-and-forget delegation, or headless b...
0 installs
documenso-prod-checklist
Execute Documenso production deployment checklist and rollback procedures. Use when deploying Documenso integrations to production, preparing for launch, or implementing go-live procedures. Trigger with phrases like "documenso production", "deploy documenso", "documenso go-live", "documenso launc...
0 installs
interactive-portfolio
Expert in building portfolios that actually land jobs and clients - not just showing work, but creating memorable experiences. Covers developer portfolios, designer portfolios, creative portfolios, and portfolios that convert visitors into opportunities. Use when: portfolio, personal website, sho...
0 installs