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rustambekurokov/esm2-8m-protein-localization
esm2-8m-protein-localization is a machine learning model from rustambekurokov. Use it for the machine learning task on the model card, and read the license before you ship it in a product. The card lists the license as mit.
Fine-tuned ESM-2 8M for protein subcellular localization (10 classes). All ESM-2 layers frozen — only the classification head was trained.
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Updated Jul 8, 2026
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From the Hugging Face model README
Fine-tuned ESM-2 8M for protein subcellular localization (10 classes). All ESM-2 layers frozen — only the classification head was trained.
| Metric | Score |
|---|---|
| Accuracy | 69.6% |
| F1 (macro) | 0.581 |
| F1 (weighted) | 0.686 |
| MCC | 0.614 |
ESM-2 8M (frozen) → Mean pooling → LayerNorm → Linear(320→80) → GELU → Linear(80→10)
| Model | Strategy | Accuracy | Link |
|---|---|---|---|
| ESM-2 8M | Linear probe | 69.6% | This repo |
| ESM-2 35M | Full fine-tune | 74.3% | whiteh4t/esm2-35m-protein-localization |
| ESM-2 150M | Full fine-tune | 76.6% | whiteh4t/esm2-150m-protein-localization |
| ESM-2 650M | LoRA (r=16) | 76.5% | whiteh4t/esm2-650m-protein-localization-lora |