SmileyLlama-1B-GGUF

SmileyLlama-1B-GGUF

GGUF quantizations of kysun63/smileyllama-1b-reproduced, a finetune of Llama-3.2-1B-Instruct.

Available quants

SmileyLlama Prompt Template

Without properties,

### Instruction:
You love and excel at generating SMILES strings of drug-like molecules

### Input:
Output a SMILES string for a drug like molecule:

### Response:

With properties, where PROPERTY_LIST is a comma-space (", ".join()) separated list of the following options:

• ( <= 3, <= 4, <= 5, <= 7, > 7) H-bond donors
• ( <= 3, <= 4, <= 5, <= 10, <= 15) H-bond acceptors
• ( <= 300, <= 400, <= 500, <= 600, > 600) Molecular weight
• ( <= 3, <= 4, <= 5, <= 10, <= 15, > 15) logP
• ( <= 7, <= 10, > 10) Rotatable bonds
• ( < 0.4, > 0.4, > 0.5, > 0.6) Fraction sp3
• ( <= 90, <= 140, <= 200, > 200) TPSA
• (a macrocycle, no macrocycles)
• (has, lacks) bad SMARTS
• lacks covalent warheads
• has covalent warheads: (sulfonyl fluorides, acrylamides, ...)
• A substructure of {SMILES_STRING}
• A chemical of {CHEMICAL_FORMULA}

List of possible warheads:

• sulfonyl fluorides: [#16](=[#8])(=[#8])-[#9]
• chloroacetamides: [#8]=[#6](-[#6]-[#17])-[#7]
• cyanoacrylamides: [#7]-[#6](=[#8])-[#6](-[#6]#[#7])=[#6]
• epoxides: [#6]1-[#6]-[#8]-1
• aziridines: [#6]1-[#6]-[#7]-1
• disulfides: [#16]-[#16]
• aldehydes: [#6](=[#8])-[#1]
• vinyl sulfones: [#6]=[#6]-[#16](=[#8])(=[#8])-[#7]
• boronic acids/esters: [#6]-[#5](-[#8])-[#8]
• acrylamides: [#6]=[#6]-[#6](=[#8])-[#7]
• cyanamides: [#6]-[#7](-[#6]#[#7])-[#6]
• chloroFluoroAcetamides: [#7]-[#6](=[#8])-[#6](-[#9])-[#17]
• butynamides: [#6]#[#6]-[#6](=[#8])-[#7]-[#6]
• chloropropionamides: [#7]-[#6](=[#8])-[#6](-[#6])-[#17]
• fluorosulfates: [#8]=[#16](=[#8])(-[#9])-[#8]
• beta lactams: [#7]1-[#6]-[#6]-[#6]-1=[#8]

### Instruction:
You love and excel at generating SMILES strings of drug-like molecules

### Input:
Output a SMILES string for a drug like molecule with the following properties: {PROPERTY_LIST}:

### Response: