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gr-hsa-prs
golden-retrievers/gr-hsa-prs
gr-hsa-prs is a machine learning model from golden-retrievers. Use it for the machine learning task on the model card, and read the license before you ship it in a product. The card lists the license as cc-by-sa-4.0.
Germline GWAS + polygenic risk scoring for canine hemangiosarcoma (HSA) on the GRLS cohort (3,224 dogs, 913,984 SNPs). Part of the golden-retrievers effort to understand HSA.
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Updated Jun 11, 2026
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At a glance
- License
- cc-by-sa-4.0
- Access
- Public
- Created
- May 31, 2026
- Updated
- Jun 11, 2026
- SHA
- 2194d3e6
Model card
From the Hugging Face model README
gr-hsa-prs
Germline GWAS + polygenic risk scoring for canine hemangiosarcoma (HSA) on the GRLS cohort (3,224 dogs, 913,984 SNPs). Part of the golden-retrievers effort to understand HSA.
Status
- GWAS (real, done): first hemangiosarcoma GWAS on GRLS Data Commons labels (306 cases / 1,329 cancer-free controls), GEMMA linear mixed model: lambda_GC = 0.955 (well-calibrated), SNP-h2 = 0.127 +/- 0.038, 0 genome-wide-significant at n=306; top signal is non-coding, consistent with the known shared HSA / B-cell-lymphoma risk on CFA5 (TRPC6/STX8).
- PRS: Clumping + Thresholding; held-out AUC 0.635 on a simulated polygenic trait (validation).
Aggregate statistics only (GRLS Data Commons DUA: no per-SNP summary statistics or individual-level data).
- Code: https://github.com/golden-retrievers/gr-hemangiosarcoma (
scripts/run_gwas.py,scripts/prs.py) - Experiments: https://wandb.ai/golden-retrievers/gr-hsa-gwas
- Data: https://huggingface.co/datasets/golden-retrievers/grls-genomics
- License
- cc-by-sa-4.0
- Created
- May 31, 2026
- Updated
- Jun 11, 2026