RiNALMo-giga

RiNALMo-giga

Minimal HuggingFace port of the giga (650.9M-parameter) variant of RiNALMo -- a general-purpose RNA language model pre-trained on 36 million non-coding RNA sequences. This is the largest and highest- quality RiNALMo checkpoint, achieving state-of-the-art results across multiple RNA downstream tasks including secondary structure prediction and splice-site detection.

Architecture

Vocabulary (index order): <cls> (0), <pad> (1), <eos> (2), <unk> (3), <mask> (4), A (5), C (6), G (7), T (8), I (9), R (10), Y (11), K (12), M (13), S (14), W (15), B (16), D (17), H (18), V (19), N (20), - (21).

Note: the tokenizer converts U -> T before encoding (the model was trained on T).

Pretraining

• Objective: Masked language modeling (BERT-style, 15% mask rate)
• Data: 36 million non-coding RNA sequences from multiple databases
• Source checkpoint: rinalmo_giga_pretrained.pt from Zenodo 15043668

Checkpoint selection

The giga variant (650.9M params) is the recommended checkpoint for best downstream performance. It achieves state-of-the-art on secondary structure prediction tasks, including generalization to unseen RNA families.

Parity Verification

All 34 representation levels (embedding + 33 transformer layers) verified to be bit-exact (max abs diff = 0.00) against a pure-PyTorch reference that loads the original weights. Weight mapping verified for all 429 per-block tensors. Eager and SDPA implementations agree within 4e-6 on padded batches.

Related Models

See the full RiNALMo collection.

Usage

Embedding generation

import torch
from transformers import AutoTokenizer, AutoModel

tokenizer = AutoTokenizer.from_pretrained("Taykhoom/RiNALMo-giga", trust_remote_code=True)
model = AutoModel.from_pretrained("Taykhoom/RiNALMo-giga", trust_remote_code=True)
model.eval()

sequences = ["ACUUUGGCCA", "CCCGGU"]
enc = tokenizer(sequences, return_tensors="pt", padding=True)

with torch.no_grad():
    out = model(**enc)

cls_emb   = out.last_hidden_state[:, 0, :]   # (batch, 1280) -- CLS token
token_emb = out.last_hidden_state             # (batch, seq_len, 1280)

# Intermediate layers
out_all = model(**enc, output_hidden_states=True)
layer20_emb = out_all.hidden_states[20]       # after block 20

MLM logits

from transformers import AutoTokenizer, AutoModelForMaskedLM

tokenizer = AutoTokenizer.from_pretrained("Taykhoom/RiNALMo-giga", trust_remote_code=True)
model = AutoModelForMaskedLM.from_pretrained("Taykhoom/RiNALMo-giga", trust_remote_code=True)
model.eval()

enc = tokenizer(["ACU<mask>UGGCCA"], return_tensors="pt")
with torch.no_grad():
    logits = model(**enc).logits   # (1, seq_len, 22)

Faster attention backends

# SDPA (PyTorch 2.0+) -- recommended for production
model = AutoModel.from_pretrained("Taykhoom/RiNALMo-giga", trust_remote_code=True,
                                   attn_implementation="sdpa")

# Flash Attention 2 (requires flash-attn package) -- fastest on long sequences
model = AutoModel.from_pretrained("Taykhoom/RiNALMo-giga", trust_remote_code=True,
                                   attn_implementation="flash_attention_2",
                                   dtype=torch.bfloat16)

Fine-tuning

Standard HF conventions. For sequence-level tasks, pool over non-padding positions or use the CLS token embedding as input to a prediction head. The original paper fine-tunes the full model for all downstream tasks.

Implementation Notes

The original RiNALMo uses Flash Attention 2.3.2 during training. This HF port exposes eager (standard PyTorch), SDPA, and Flash Attention 2 through HuggingFace's attn_implementation dispatch. SDPA and the dispatch interface are additions; the Flash backend preserves the original non-causal Flash Attention design.

The model uses a non-standard Pre-LN residual: the attention residual connection is taken from the normalized input (i.e., x = attn_ln(x); x = x + attn(x)) rather than the original. The FFN uses standard Pre-LN.

TokenDropout rescales embeddings by (1 - mask_ratio_train) / (1 - mask_ratio_observed) even at inference, consistent with the original training code.

Citation

@article{penic2025_rinalmo,
  title   = {RiNALMo: general-purpose {RNA} language models can generalize well on structure prediction tasks},
  author  = {Penić, Rafael Josip and Vlašić, Tin and Huber, Roland G. and Wan, Yue and Šikić, Mile},
  journal = {Nature Communications},
  volume  = {16},
  number  = {1},
  pages   = {5671},
  year    = {2025},
  doi     = {10.1038/s41467-025-60872-5}
}

Credits

Original model and code by Penić et al. Source: GitHub lbcb-sci/RiNALMo. Hugging Face port maintained by Taykhoom Dalal.

License

Apache 2.0 (code) / CC BY 4.0 (model weights), following the original repository.