DistillPath-IS16-Virchow2

DistillPath-IS16-Virchow2

A 22M ViT-S/16 pathology tile encoder distilled from Virchow2 (632M ViT-H/14) into an ImageNet-21k pretrained ViT-S/16 student using backbone-token distillation on 6,000 public TCGA slides.

This is the ImageNet-initialized variant. For the kaiko-initialized variant, see DistillPath-KS16-Virchow2.

Paper: DistillPath: An Efficient 22M Distilled Pathology Encoder Approaching Large Foundation Model Performance Ramon Kaspar, Andrey Ignatov, Valentina Boeva. ETH Zurich. Published at the ECCV 2026 Workshop on Medical Foundation Models and Benchmarks (MedFM-Bench).

Model details

Benchmark results

See the paper for per-task results.

Usage

Load directly from the Hub with timm:

import timm

model = timm.create_model(
    "hf_hub:RamonK/DistillPath-IS16-Virchow2",
    pretrained=True,
    num_classes=0,
)
model.eval()

Or load manually:

import timm
from huggingface_hub import hf_hub_download
from safetensors.torch import load_file

model = timm.create_model("vit_small_patch16_224", pretrained=False, num_classes=0)
path = hf_hub_download("RamonK/DistillPath-IS16-Virchow2", "model.safetensors")
state_dict = load_file(path)
model.load_state_dict(state_dict, strict=True)
model.eval()

This model uses ImageNet normalization: mean=(0.485, 0.456, 0.406), std=(0.229, 0.224, 0.225).

from torchvision import transforms

transform = transforms.Compose([
    transforms.Resize(224),
    transforms.CenterCrop(224),
    transforms.ToTensor(),
    transforms.Normalize(mean=[0.485, 0.456, 0.406], std=[0.229, 0.224, 0.225]),
])

Distillation recipe

The recipe reads only the teacher's final class and patch tokens (no teacher pretraining heads required):

• Class-token loss: cosine distance + RKD (relational knowledge distillation)
• Patch-token loss: cosine distance after bicubic grid resizing (teacher 16x16 to student 14x14)
• Optimizer: AdamW, lr=1e-4, weight decay 0.05, cosine decay, 500 warmup steps
• Projector: DINO-style MLP (384 to 2048 to 2048 to 256 to d_t), discarded after training

Full details in the paper and the DistillPath repository.

License

This model is released under the Creative Commons Attribution-NonCommercial 4.0 International License. The Virchow2 teacher is released under CC BY-NC-ND 4.0. The distillation process used Virchow2 only to generate supervisory outputs; the released student contains no Virchow2 weights. This model is intended solely for non-commercial academic research.

Citation

@inproceedings{kaspar2026distillpath,
  title     = {DistillPath: An Efficient 22M Distilled Pathology Encoder Approaching Large Foundation Model Performance},
  author    = {Kaspar, Ramon and Ignatov, Andrey and Boeva, Valentina},
  booktitle = {Medical Foundation Models and Benchmarks (MedFM-Bench), ECCV 2026},
  year      = {2026}
}