esm2_t33_650M_UR50D

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Discovery stage: Target identification

Meta's ESM-2 protein language model. Per-residue embeddings that transfer to binding-site prediction, variant-effect scoring and structure-aware target featurisation.

Upstream: facebook/esm2_t33_650M_UR50D - all credit to the original authors; the model card and licence below are theirs.

Explore the rest of the catalogue: Molecule Explorer - Protein Target Explorer - Drug Discovery Model Hub

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ESM-2

ESM-2 is a state-of-the-art protein model trained on a masked language modelling objective. It is suitable for fine-tuning on a wide range of tasks that take protein sequences as input. For detailed information on the model architecture and training data, please refer to the accompanying paper. You may also be interested in some demo notebooks (PyTorch, TensorFlow) which demonstrate how to fine-tune ESM-2 models on your tasks of interest.

Several ESM-2 checkpoints are available in the Hub with varying sizes. Larger sizes generally have somewhat better accuracy, but require much more memory and time to train: